Laboratory of Immunorheumatology and tissue regeneration

Laboratorio di Immunoreumatologia e rigenerazione tissutale

The Laboratory

The Laboratory of Immunorheumatology and Tissue Regeneration (LITR - formerly Laboratory of Immunology and Genetics) is part of the Department of Complex Orthopedic Pathologies of the Rizzoli Orthopedic Institute.

It was established in 1988, following an agreement with the University of Bologna and, since 1989, it has been based at the Codivilla-Putti Institute  of the Rizzoli Orthopedic Institute.

The Laboratory, being a University-run structure, carries out training activities in the Biomedical, Biotechnological and Healthcare profession area.

The Laboratory carries out bio-medical and bio-technological research in the area of inflammatory and degenerative diseases of the musculoskeletal system and in the field of regenerative medicine. To this end it cooperates with Clinical Units and other research laboratories of the IOR, as well as both national and international universities and research institutes.


Since its establishment, the main research topics of the group have included:

  • the study of the etiopathogenetic mechanisms of musculoskeletal diseases with great social impact
  • the analysis of pathophysiological changes in the immune system during aging and in osteoarticular pathologies
  • the development of innovative therapies in orthopedics, such as tissue engineering. 

Excellence activity

Over the years, the Laboratory has pursued a specialization in the study of the aforementioned themes and therefore proposes itself as a Reference Center for the study of osteoarticular diseases. 

Furthermore, the Laboratory is part of the IOR Biological Resource Center group and manages the collection of biological material from patients with Rheumatoid Arthritis, linked to the Regional Registry of rheumatological diseases and treatments (BUR, June 1, 2017).

Since 2003, advanced histological analysis with rheumatological orientation  has been carried out on synovial tissue samples. Anatomo-pathologists and the rheumatologists jointly participate to this activity.

Know how

Researchers have  the appropriate know-how for planning, drafting and reporting national and international research projects on a competitive basis, also in the industrial field.

Research projects developed by the Laboratory are mainly funded  by Ministry of Health, MIUR, University of Bologna, Bank Foundations, European Union and Companies.


Since 2008 the Laboratory has obtained the conformity certification to the UNI EN ISO 9001: 2000 standard and subsequent amendments, for the management of pre-clinical research projects in the biomedical, technological, bioinformatic and pharmaceutical fields, for the management of clinical and organizational studies, for biobanking activities, diagnostic activities and test execution for third parties.

The Laboratory of Immunorheumatology and Tissue Regeneration Guide can be downloaded in the Documents section below.

Content updated 21/08/2020 - 13:12
Content edited by: Dott. Paolo Dolzani (
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