Photo of Erminia Mariani, MD
Erminia Mariani, MD
+39-051-6366803
+39-051-6366807

Publications 2014-2009

  • Alessandra Longhi; Marcus Reif; Erminia Mariani; Stefano Ferrari. A randomized study on postrelapse disease-free survival with adjuvant mistletoe versus oral etoposide in osteosarcoma patients. Evidence-based Complementary and Alternative Medicine. 2014.
  • R. Giacconi; L. Costarelli; M. Malavolta; F. Piacenza; R. Galeazzi; N. Gasparini; A. Basso; E. Mariani; T. Fulop; L. Rink; G. Dedoussis; S. Kanoni; G. Herbein; J. Jajte; F. Busco; E. Mocchegiani. Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population. Biogerontology. 2014;15(1):65-79.
  • Carola Cavallo; Giuseppe Filardo; Erminia Mariani; Elizaveta Kon; Maurilio Marcacci; Maria Teresa Pereira Ruiz; Andrea Facchini; Brunella Grigolo. Comparison of platelet-rich plasma formulations for cartilage healing: An in vitro study. Journal of Bone and Joint Surgery - Series A. 2014;96(5):423-429.
  • Erminia Mariani; Lia Pulsatelli; Andrea Facchini.  Signaling  pathways in cartilage repair. International Journal of Molecular Sciences. 2014;15(5):8667-8698.
  • Elisa Assirelli; Giuseppe Filardo; Erminia Mariani; Elizaveta Kon; Alice Roffi; Franca Vaccaro; Maurilio Marcacci; Andrea Facchini; Lia Pulsatelli. Effect of two different preparations of platelet-rich plasma on synoviocytes. Knee Surgery, Sports Traumatology, Arthroscopy. 2014.
  • Alice Roffi; Giuseppe Filardo; Elisa Assirelli; Carola Cavallo, Annalisa Cenacchi;  Andrea Facchini; Brunella Grigolo; Elizaveta Kon; Erminia Mariani; Loredana Pratelli; Lia Pulsatelli ; Maurilio Marcacci. Does platelet-rich plasma freeze-thawing influence growth factor release and their effects on chondrocytes and synoviocytes?  Biomed Res. Int. 2014, e-pub.
  • Mariani E., Filardo G., Canella V., Berlingeri A., Bielli A., CattiniL., Landini M.P., Kon E., Marcacci M., Facchini A. Platelet rich plasma affects bacterial growth in vitro. Cytotherapy 16, 1294-1304, 2014.   
  • Peter Uciechowski; Eva Maria Oellig; Erminia Mariani; Marco Malavolta; Eugenio Mocchegiani; Lothar Rink. Effects of human Toll-like receptor 1 polymorphisms on ageing. Immunity and Ageing. 2013;10(1).
  • Francesca Perut; Giuseppe Filardo; Erminia Mariani; Annarita Cenacchi; Loredana Pratelli; Valentina Devescovi; Elizaveta Kon; Maurilio Marcacci; Andrea Facchini; Nicola Baldini; Donatella Granchi. Preparation method and growth factor content of platelet concentrate influence the osteogenic differentiation of bone marrow stromal cells. Cytotherapy. 2013;15(7):830-839.
  • Simona Neri; Philippe Bourin; Julie-Anne Peyrafitte; Luca Cattini; Andrea Facchini; Erminia Mariani.  Human Adipose Stromal Cells (ASC) for the Regeneration of Injured Cartilage Display Genetic Stability after In Vitro Culture Expansion. PLoS ONE. 2013;8(10).
  • Mariani E., Facchini A. Clinical applications and biosafety of human adult mesenchymal cells. Curr. Phar. Des. 18, 1821-1845, 2012.
  • Paola Forti; Gian L. Pirazzoli; Benedetta Maltoni; Giampaolo Bianchi; Donatella Magalotti; Antonio Muscari; Erminia Mariani; Giovanni Ravaglia; Marco Zoli. Metabolic syndrome and all-cause mortality in older men and women. European Journal of Clinical Investigation. 2012;42(9):1000-1009.
  • Neri S., Mariani E., Cattini L., Facchini A. Long-term in vitro expansion of osteoarthritic human articular chondrocytes do not alter genetic stability: a microsatellite instability analysis. J. Cell. Physiol 226, 2579-2585, 2011.
  • Forti P., Rietti E., Pisacane N., Olivelli V. Mariani E., Chiappelli M:, Licastro F., Ravaglia G. Blood inflammatory proetins and risk of incedent depression in the elderly. Dement. Geriatr. Cogn. Disord. 29, 11-20, 2010.
  • Forti P., Pisacane N., Rietti E., Lucisarese A., Olivelli V. Mariani E., Mecocci P., Ravaglia G. Metabolic Syndrome and risk of dementia in older adults. J. Am. Geriatr. Soc. 58, 487-492, 2010.
  • Kanoni S, Dedoussis GW, Herbein G., Fulop T., Varin A., Jaite J, Rink L., Monti D., Mariani E, Malavolta M:, Giacconi R, Marcellini F., Mocchegiani E. Assessment of gene-nutrient interaction on inflammatory status of the elderly with the use of a zinc diet score – ZINCAGE study. J. Nutr. Biochem. 21, 526-531, 2010.
  • Longhi A., Mariani E., Kuehn J., A randomized study with adjuvant mistletoe versus oral Etoposide on post relapse disease-free serviva in osteosarcoma petients. Eur J, Integr. Med. 1, 31-39, 2009.

Publications 2008-2006

  • Mariani E., Neri S., Cattini L, Mocchegiani E., Malavolta M., Dedoussis G.V., Kanoni S., Rink L., Jajte J., Facchini A. Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and –174 IL-6 polymorphic alleles. Exp. Gerontol. 43, 462-471, 2008.
  • Mocchegiani E., Giacconi R., Costarelli L., Muti E., Cipriano C., Tesei S., Pierpaoli S., Giuli C., Papa R., Marcellini F., Gasparini N., Pierandrei R., Piacenza F., Mariani E., Monti D., Dedoussis G., Kanono S., Herbein G., Fulop T., Rink L., Jaite J., Malavolta M. Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study. Exp Gerontol. 43, 433-444, 2008.
  • Mocchegiani E. and the Zincage Consortium (Malavcolta, Giacconi….Mariani…Aspinall, Pawelec), Zinc, metallothioneins, longevity: effect of zinc supplementation on antioxidant response – a Zincage study. Rejuvenation Res., 11, 419-423, 2008.
  • Neri S., Pawelec G., Facchini A., Ferrari C., Mariani E. Altered expression of Mismatch Repair Proteins associated with acquisition of Microsatellite Instability in a clonal model of human T lymphocyte ageing. Rejuvenation Res., 11, 565-572, 2008.
  • Dedoussis G.V., Kanoni S., Mariani E., Cattini L., Herbein G., Fulop TR., Varin A., Rink L., Jaite J., Monti D., Marcellini F., Malavolta M., Mocchegiani E. Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study. Clin. Chem. Lab. Med., 2008 may 21 (Epub ahead of print).
  • Ravaglia G., Forti P., Maioli F., Chiappelli M., Montesi F., Tumini E., Mariani E., Licastro F., Patterson C. Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging. Neurobiol. Aging, 28, 1810-1820, 2007.
  • Neri S., Pawelec G., Facchini A., Mariani E. Microsatellite instability and compromized mismatch repair gene expressione during in vitro passaging of monoclonal human T lymphocytes. Rejuvenation Res., 10 (2), 145-156, 2007.
  • Giacconi R., Muti E., Malavolta M., Cipriano C., Costarelli L., Bernardini G., Gasparini N., Mariani E., Saba V., Boccoli G., Mocchegiani E. The +838 C/G MT2A polymorphism, metals and the inflammatory immune response in carotid artery stenosis in elderly people. Mol. Med., 13, 388-395, 2007.
  • Moccehgiani E., Giacconi R., Cipriano C., Muti E., Tesei S., Papa R., Marcellini F., Mariani E., Rink L., Herbein G., Varin A., Fulop T., Monti D., Jaite J., Dedoussis G., Gonos E.S. Trougakos I.P., Malavolta M. Zinc, metallothioneins and longevity – effect of zinc supplementation: zincage study. Ann. N. Y. Acad. Sci., 1119, 129-46, 2007.
  • Burkle A., Caselli G., Franceschi C., Mariani E., Sansoni P., Santoni A., Vecchio G., Witkowski J.M., Caruso C. Pathophysiology of ageing, longevity and age related diseases. Immunity and Ageing, 4:4, 2007.
  • Mariani E., Cattini L., Neri S., Malavolta M., Mocchegiani E., Ravaglia G., Facchini A. Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status. Biogerontology., 7, 449-459, 2006.
  • Delarosa O., Pawelec G., Peralbo E., Wikby A., Mariani E., Mocchegiani E., Tarazona R., Solana R. Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology., 7, 471-481, 2006.
  • Cipriano C., Malavolta M., Costarelli L., Giacconi R., Muti E., Gasparini N., Cardelli M., Monti D., Mariani E., Mocchegiani E. Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. Biogerontology., 7, 357-365, 2006.
  • Ravaglia G., Forti P., Maioli F., Martelli M., Servadei L., Brunetti N., Pantieri G., Mariani E. Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. Dement. Geriatr. Cogn Disord., 21, 51-58, 2006.

Publications 2005-2003

  • Neri S., Gardini A., Facchini A., Olivieri F., Franceschi C., Ravaglia G., Mariani E. Mismatch repair system and ageing: microsatellite instability in peripheral blood cells from differently aged participants. J. Gerontol. A Biol. Sci. Med. Sci. 60, 285-292, 2005.
  • Ravaglia G, Forti P., Maioli F., Brunetti N., Martelli M., Servadei L., Bastagli L., Mariani E.  Serum C-reactive proteinand cognitive function in healthy elderly Italian community dwellers. J. Gerontol. A Biol. Sci. Med. Sci. 60, 1017-1021, 2005.
  • Ravaglia G, Forti P., Maioli F., Martelli M., Servadei L., Brunetti N., Dalmonte E., Bianchin M., Mariani E.  Incidence and etiology of dementia in a large elderly Italian population. Neurology 64, 1525-1530, 2005.
  • Ravaglia G, Forti P., Maioli F., Servadei L., Martelli M., Brunetti N., Bastagli L., Cucinotta D., Mariani E.  Folate, but not homocysteine, predicts the risk of fracture in elderly persons. J. Gerontol. A Biol. Sci. Med. Sci. 60, 1458-1462, 2005.
  • Lisignoli G., Cristino S., Toneguzzi S., Grassi F., Piacentini A., Cavallo C., Facchini A., Mariani E. IL1-b and TNF-a differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from Osteoarthritis patients: evidence of changes associated to cell maturation. Exp. Ger. 39, 659-665, 2004.
  • Neri S., Cattini L., Facchini A., Pawelec G., Mariani E. Microsatellite instability in 'in vitro' ageing of T lymphocyte clones. Exp. Ger. 39, 499-505,  2004.
  • Pawelec G., Mariani E., McLeod J., Ben-Yeuda A., Fulop T., Aringer M., Barnett Y. Engeneering anti-cancer T cells for extended functional longevity. Ann. N. Y. Acad. Sci. 1019, 178-185, 2004.
  • Pulsatelli L., Dolzani P., Silvestri T., Caraceni P., Facchini A., Ravaglia G., Salvarani C., Meliconi R., Mariani E. Soluble Receptor Activator of Nuclear  Factor-kB Ligand. (sRANKL)/Osteoprotegerin balance in ageing and age-associated diseases. Biogerontology 5, 119-127, 2004.
  • Ravaglia G, Forti P., Maioli F., BianchiG.,  Martelli M., Talerico T., Servadei L., Zoli M., Mariani E. Plasma aminoacid concentrations in patients with amnestic mild cognitive impairment or Alzheimer disease. Am. J. Clin. Nutr. 80, 483-488, 2004.
  • Ravaglia G, Forti P., Maioli F., Brunetti N., Martelli M., Talerico T., Bastagli L., Muscari A., Mariani E. Peripheral blood markers of inflammation and functional impairment in elderly community-dwellers. Exp. Gerontol. 9, 1415-1422, 2004.
  • Ravaglia G, Forti P., Maioli F., Servadei L:, Martelli M., Arnone G., Talerico T., Zoli M., Mariani E.  Plasma homocysteine and inflammation in elderly patients with cardiovascular dosease and dementia. Exp. Gerontol. 39, 443-450, 2004.
  • Lisignoli G., Piacentini A., Toneguzzi S., Grassi F., Tschon M., Cristino S., Facchini A., Mariani E. Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts. Biogerontology 4, 309-317, 2003.
  • Mariani E., Meneghetti A., Formentini I., Neri S., Cattini L., Ravaglia G., Forti P., Facchini A. Telomere length and telomerase activity: effect of ageing on human NK cells. Mech. Ageing. Dev. 124, 403-408, 2003.
  • Mariani E., Meneghetti A., Formentini I., Neri S., Cattini L., Ravaglia G., Forti P., Facchini A. Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing. Exp. Ger. 38, 653-659, 2003.
  • Ravaglia G, Forti P., Maioli F., Arnone G., Pantieri G., Cocci C., Nativio V., Muscari A., Pedone V., Mariani E.  The clock-drawing test in elderly Italian community dwellers: associations with sociodemographic status and risk factors for vascular cognitive impairment. Dement. Geratr. Cogn. Disord. 16, 287-295, 2003.
  • Ravaglia G, Forti P., Maioli F., Muscari A., Sacchetti L., Arnone G., Nativio V., , Talerico T., Mariani E. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. Am. J. Clin. Nutr. 77, 668-673, 2003.
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