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The Institute has two buildings (Rizzoli hospital and Codivilla-Putti research centre) a few hundred meters apart.

The Hospital is in via G.C.Pupilli 1, in Bologna (Italy), outside the old city gate of San Mamolo.

The Codivilla-Putti research centre is in via di Barbiano 1/10, outside the old city gate of Castiglione, in a building that, besides the laboratories, houses the head office, administration and outpatients’ clinic.

Furthermore the Rizzoli Orthopaedic Institute is responsible of the orthopaedic ward of the Hospital of Bentivoglio, a small town near Bologna.