Regenerative medicine in orthopaedic diseases

Medicina rigenerativa in patologie ortopediche - menù


Chondral and osteochondral lesions still constitute a major problem in orthopaedics. These lesions can affect all the joints and can involve only the articular cartilage or also the subchondral bone. Conventional orthopaedic techniques usually applied to treat osteochondral lesions (eg: microfractures, drilling) can restore a tissue with different biomechanical properties (i.e.: fibrocartilage vs hyaline cartilage) that can lead to cartilage degeneration and bone remodeling. Regenerative medicine is a new surgical approach for treating cartilage, bone or tendon diseases using different  techniques based on the combination of biomaterials with different cell populations and growth factors.

In this programme we intend to evaluate, in 4 controlled studies on patients with specific diseases affecting articular cartilage and subchondral bone (3 clinical trials and 1 longitudinal study), the treatment based on the use of growth factors, autologous cells and scaffolds.

The final REMOD event will be held on Wednesday, April 19th 2017 at the Rizzoli Orthopaedic Institute (see the program in Italian).

Use of platelet rich plasma (PRP) for the repair of cartilage lesions

Treatment of osteochondral knee lesions with a new biomimetic three-layered osteochondral scaffold

“One-step” bone marrow mononuclear cell transplantation in talar osteochondral lesions

Treatment of early and advanced osteonecrosis of the femoral head with regenerative medicine

Production and validation of concentrated bone marrow cells, platelet rich products and bone derivatives