Brunella Grigolo, PhD

Photo of Brunella Grigolo PhD
Brunella Grigolo, PhD
+39-051-6366803
+39-051-6366803

Personal information - Education and work experience

06/01/1956
PhD, Biologist

Person in charge of the organization, RAMSES Laboratory, Rizzoli Orthopedic Institute, Bologna

1980: Degree in Biological Science, University of Bologna, Italy.

  • 1987: Specialization in Biochemistry and Clinical Chemistry, University of Parma.
  • 1992: Registration in the National Registry of Biologists.
  • 2007: Technical Director of Pharmaceutical production for Advanced Therapies (Italian Pharmaceutical Agency).
  • 2012: National Scientific Qualification for Associate Professor in Histology, General Pathology, Applied Biology, Health applied medical profession.
  • From 2012: Person in charge of the organization, RAMSES Laboratory, Department of Research and Innovation Technology, Rizzoli Orthopaedic Institute.
  • From 2009: Biology Research Manager. Special qualification in 'Physiopathology and cartilage Regeneration”. Immunorheumatology and Tissue Regeneration Laboratory, Rizzoli Orthopaedic Institute.
  • 1999-2009. Biology Research Manager. Person in charge of the Researches on human and animal chondrocyte transplantation. Human and animal chondrocyte cell cultures. Preclinical animal models for tissue engineering therapeutic strategies. Analyses of bio-molecular markers involved in osteoarticular pathologies. Immunology and Genetics Laboratory (presently, Immunorheumatology and Tissue Regeneration Laboratory) Rizzoli Orthopaedic Institute.
  • 1991-1999. Biology Research Manager. Researches on Immunology, Regenerative Medicine. Immunology and Genetics Laboratory (presently, Immunorheumatology and Tissue Regeneration Laboratory) Rizzoli Orthopaedic Institute.
  • 1982-1990. Fellow. Biochemical and Clinical Laboratory, Gastroenterology Unit, Medical Department, Policlinico S. Orsola, Bologna, Italy.
  • 1980-1982. Biologist, S. Vitale Laboratory, Budrio (Bologna), Italy.

English: fluent.

French: fluent.

Excellent skills in the applications of tools for word processing, database management, graphical systems and statistical computing (Microsoft Office, Photoshop, etc).

  • 2003-2010: Teacher at the Rheumatology Specialization School, University of Bologna.
  • Teacher for Laboratory Technician School and for Medical School, University of Bologna.
  • Assistant Supervisor for Degree Thesis: Science, Medicine, Pharmacy, Biotechnology. University of Bologna.
  • Invited speaker in several Italian Universities. 
  • 1997-1999: Target research project of the Italian Health Ministry: “Autologous chondrocyte transplantation in joint cartilage defects”.
  • 1999-2001: Target research project of the Italian Health Ministry: “Pathogenesis and therapeutic strategies in rheumatic polimyalgia”.
  • 2000-2002: Target research project of the Italian Health Ministry: “Tissue engineering in orthopaedics”.
  • 2002-2005: “STEMGENOS” Project, European Union FP5 (QLK3-CT-2002-02039)
  • 2005-2009: “STEPS” Project, European Union FP 6 (NMP3-CT-2005-500465).
  • 2003-2005: Basic research investment fund (BRIF), Italian MIUR: “Development of a line of normal human immortalised chondrocytes for tissue engineering utilization”.
  • 2005-2007: Basic research investment fund (BRIF), Italian MIUR: “Mesenchymal stem cells in tissue engineering for the prevention of cartilage damages”.
  • 2006-2008: Basic research investment fund (BRIF), Italian MIUR: “Adult mesenchymal stem cells 'MSC' for tissue engineering in musculoskeletal pathologies”.
  • 2006-2008: Basic research investment fund (BRIF), Italian MIUR: “Prevention of obesity complications: study of the lipidic metabolism and osteoarticular pathology”.
  • 2008-2009: Responsible of Operative Unit of the Italian Health Ministry Project: “Tissue engineering in osteoarticular disease: basic and clinical evaluation”.
  • 2008-2010: Responsible of Operative Unit of the Project Region Emilia Romagna-University: “Regenerative Medicine in Osteoarticular diseases”.
  • 2011-2013: Responsible of Operative Unit of the Italian Health Ministry Project: “Development of novel methodolgy for the translation of adult stem cell therapy to the clinical regeneration of cartilage”.
  • 2011-2013: Responsible of research in the Italian Health Ministry Project: “Platelet rich plasma, from clinical application to research and back: a new non-surgical bioactive treatment for knee cartilage degeneration and osteoarthritis”.
  • 2010-2014. “Adipose derived stromal cells for osteoarthritis treatment” (ADIPOA) Project European Union FP 7.
  • 2012-2014. Responsible of Operative Unit of the Project Region Emilia Romagna-University: “Regenerative medicine of cartilage and bone”.

References:
108 Publications “in extenso”, 16 book chapters, 125 abstracts.

Patent:
Patent n. MI2007A000458 "Composition containing autologous mononuclear cells and pig collagen scaffold in paste form and its use in the preparation of a medicament for surgical treatment".

Reviewer of Scientific Journals:
Biomaterials, Clinical Orthopaedic & Related Research, Journal of Rheumatology, Journal of Immunology, Scandinavian Journal of Rheumatology, Histology and Histopathology, Life Sciences, Biotechnology and Bioengineering, Osteoarthritis and Cartilage, Journal of Orthopaedic Research, International Journal of Artificial Organs, Journal Biomedical Material Research, Journal of Cell Physiology, Biomacromolecules, Journal of Cellular and Molecular Medicine, Journal of Clinical Rehabilitative Tissue Engineering Research, BMC Muskuloskeletal Disorders, Cell and Tissue Research, Tissue Engineering, Stem Cell International, Cell Biochemistry and Biophysics, Plos One, Cytotechnology, Advances in Orthopedics, Regenerative Medicine, Journal of Tissue Engineering and Regenerative Medicine, Future Medicine, Arthritis Research Therapy, Biotechnology and Molecular Biology.

Evaluation boards for assignment of research funds:
From 2002: Italian Ministry of health MIUR (Art.7; DDL 297/99).
From 2006: Research Grants Council (RGC), Hong Kong.

Patent:
Italian Patent n. MI2007A000458 and PCT procedure of “Composition containing autologous mononuclear cells in swine pastry matrices and its use in the preparation of a medicine for surgical treatment”. 

Regenerative medicine in the orthopedic field with particular interest in cartilage and bone repair and on the use of different cell type and biomaterials. Cell cultures: chondrocytes, synoviocytes, ligament and tendon cells. Mesenchymal stem cells from bone marrow and adipose tissue.
Research on the development of Osteoarthritis and other cartilage pathologies and development of new strategies for their treatment. Histochemistry and immunohistochemistry, molecular biology techniques. 3D bioprinting.

Content updated 14/07/2016 - 15:32
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