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In the laboratory are active various research activities aimed at identifying markers of early diagnosis, prognosis and potential therapeutic targets and progression of some osteoarticular pathologies. To this end, phenotypic and functional characterization tests are performed on cell populations involved in the development of various diseases of the musculoskeletal system; studies to analyze the molecular mechanisms involved in the pathogenesis or response to therapies. In the laboratory methods of protein isolation, characterization, identification and quantification are applied. In particular, we perform protein extraction from cells and tissues, separation of proteins by classic techniques of polyacrylamide gel electrophoresis. Functional evaluations are performed through the analysis of soluble factors, such as cytokines, chemokines and growth factors, released at the joint level.


Figure 7: Study of biomarkers of bone metabolism. Role of hydrogen sulfide

Figure 8: Identification of biomarkers of activity and progression of musculoskeletal disorders