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Grigolo Brunella, PhD


Date of Birth

PhD, Biologist

Current assignment

Person in charge - RAMSES Laboratory

Title of qualification awarded

1980: Degree in Biological Science, University of Bologna, Italy.

Other qualifications awarded
  • 1987: Specialization in Biochemistry and Clinical Chemistry, University of Parma.
  • 1992: Registration in the National Registry of Biologists.
  • 2007: Technical Director of Pharmaceutical production for Advanced Therapies (Italian Pharmaceutical Agency).
  • 2012: National Scientific Qualification for Associate Professor
    • Histology
    • General Pathology
    • Applied Biology
    • Health applied medical profession.
Positions held
  • From 2012: Person in charge of the organization, RAMSES Laboratory, Department of Research and Innovation Technology, Rizzoli Orthopaedic Institute.
  • From 2009: Biology Research Manager. Special qualification in 'Physiopathology and cartilage Regeneration”. Immunorheumatology and Tissue Regeneration Laboratory, Rizzoli Orthopaedic Institute.
  • 1999-2009. Biology Research Manager. Person in charge of the Researches on human and animal chondrocyte transplantation. Human and animal chondrocyte cell cultures. Preclinical animal models for tissue engineering therapeutic strategies. Analyses of bio-molecular markers involved in osteoarticular pathologies. Immunology and Genetics Laboratory (presently, Immunorheumatology and Tissue Regeneration Laboratory) Rizzoli Orthopaedic Institute.
  • 1991-1999. Biology Research Manager. Researches on Immunology, Regenerative Medicine. Immunology and Genetics Laboratory (presently, Immunorheumatology and Tissue Regeneration Laboratory) Rizzoli Orthopaedic Institute.
  • 1982-1990. Fellow. Biochemical and Clinical Laboratory, Gastroenterology Unit, Medical Department, Policlinico S. Orsola, Bologna, Italy.
  • 1980-1982. Biologist, S. Vitale Laboratory, Budrio (Bologna), Italy.

English: fluent.

French: fluent.


Excellent skills in the applications of tools for word processing, database management, graphical systems and statistical computing (Microsoft Office, Photoshop, etc).

Teaching activities
  • 2003-2010: Teacher at the Rheumatology Specialization School, University of Bologna.
  • Teacher for Laboratory Technician School and for Medical School, University of Bologna.
  • Assistant Supervisor for Degree Thesis: Science, Medicine, Pharmacy, Biotechnology. University of Bologna.
  • Invited speaker in several Italian Universities. 
Scientific activities
Management of Research projects of the Ministry of Health, the Emilia-Romagna Region, the European Community, National Bodies and National and International Enterprises as Project Manager orexceutive manager.


  • She is the author of 137 publications on scientific journals, 125 abstracts presented at conferences, 16 book chapters
  • H Index: 31 (Scopus 2020).
Patent n. MI2007A000458 "Composition containing autologous mononuclear cells and pig collagen scaffold in paste form and its use in the preparation of a medicament for surgical treatment".
Reviewer of Scientific Journals among which: Biomaterials, Clinical Orthopaedic & Related Research, Journal of Rheumatology, Journal of Immunology, Scandinavian Journal of Rheumatology, Histology and Histopathology, Life Sciences, Biotechnology and Bioengineering, Osteoarthritis and Cartilage, Journal of Orthopaedic Research, International Journal of Artificial Organs, Journal of Biomedical Material Research, Journal of Cell Physiology, Biomacromolecules, Journal of Cellular and Molecular Medicine, Journal of Clinical Rehabilitative Tissue Engineering Research, BMC Muskulo-skeletal Disorders, Cell and Tissue Research, Tissue Engineering, Stem Cell International, Cell Biochemistry and Biophysics, Plos One, Cytotechnology, Advances in Orthopedics, Regenerative Medicine, Journal of Tissue Engineering and Regenerative Medicine, Future Medicine, Arthritis Research Therapy, Biotechnology and Molecular Biology.


Evaluation boards for assignment of research funds:
  • From 2002: Italian Ministry of Health - MIUR (Art.7; DDL 297/99)
  • From 2006: Research Grants Council (RGC), Hong Kong.
Clinical and/or Scientific interests

Regenerative medicine in the orthopedic field with particular interest in cartilage and bone repair and on the use of different cell type and biomaterials. Cell cultures: chondrocytes, synoviocytes, ligament and tendon cells. Mesenchymal stem cells from bone marrow and adipose tissue.
Research on the development of Osteoarthritis and other cartilage pathologies and development of new strategies for their treatment. Histochemistry and immunohistochemistry, molecular biology techniques. 3D bioprinting.

Training events

Promotore/organizzatore dei seguenti eventi formativi.

Immagine locandina ICRS Focus Meeting (particolare)
ICRS Focus Meeting Ortho-Biologics
From the Laboratory to the Clinics: New Insight into Translational Research toward Bio-Orthopaedics
from Thursday - 6 October 2022 to Friday - 7 October 2022
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