Laginestra Maria Antonella, PhD

Laboratory of Experimental Oncology

E-mail address: mariaantonella.laginestra@ior.it

Date of Birth

03/10/1975

Qualification

Biologist-Bioinformatician

Current assignment

Researcher

Title of qualification awarded

Currently enrolled in an International Master in Bioinformatics at the University of Bologna
2004: Degree in Biological Sciences, at the University of Pisa.

Other qualifications awarded

2013: PhD in Clinical and Experimental Hematology and Hemopathology, at the University of Bologna
2009: Specialization in Medical Genetics
2006: Qualification as Biologistat the University of Bologna.

Positions held

From 2020: Researcher at the Laboratory of Experimental Oncology of the Rizzoli Orthopaedic Institute. Project: Bioinformatic analysis of RNA-Seq data
2016-19: Researcher at the Molecular Pathology laboratory, Department of Hematology and Oncological Sciences “L. & A. Seràgnoli", University of Bologna. Project: “Innovative approaches to the diagnosis and pharmacogenetic-based therapies of primary hepatic tumours, peripheral B and T-cell lymphomas and lymphoblastic leukaemias”
2015-16: Researcher at the Clinical Hematoncology laboratory unit, European Institute of Oncology (IEO), Milan. Project: “Blastic Plasmacytoid dendritic cell neoplasm: from genomics to therapy”
2013-15: Research fellow at the Molecular Pathology laboratory, Department of Hematology and Oncological Sciences “L. & A. Seràgnoli ", University of Bologna. Project: "Massive genome sequencing of hemato-lymphoid tumors"
2013: Fellowship provided by ABSTE (Associazione Bolognese Studi Tumori Ematologici - Bolognese Association for Hematological Tumor Studies) at the Molecular Pathology laboratory Department of Hematology and Oncological Sciences "L. & A. Seràgnoli", University of Bologna. Project: "Genetic-molecular characterization of peripheral T-cell lymphomas"
10-12: Fellowship for the PhD in Biomedical Sciences: Clinical and Experimental Hematology and Hematopathology, University of Bologna. Project: microRNA Profiling in Peripheral T Cell Lymphomas.

Languages

Good knowledge of written and spoken English.

Technologies

Bioinformatics skills:

Operating systems: UNIX (Linux e OSX), Microsoft Windows
Programming languages: Bash, R, Python
Use of specific pipelines for Whole Exome sequencing, RNA-sequencing, Targeted Resequencing data analysis
Use of the R (Bioconductor) package for gene expression analysis.

Molecular Biology Skills - High throughput techniques:

Whole Exome (WES) and Whole Transcriptome (RNA-seq) Sequencing: libraries preparation, quantification (Picogreen, RealTime and Qubit) and validation (Bioanalyzer); sequencing platforms NextSeq 500 and MiSeq (Illumina)
Gene Expression Profiling and microRNAs profiling using Affymetrix and Illumina (DASL for FFPE samples) technology.

Scientific activities

Author of 24 papers listed on PubMed.