Two patients, both 34 years old, were treated at the Rizzoli-Sicilia Department in Bagheria by a multidisciplinary team of orthopedic oncology surgeons, radiologists, oncologists, anesthetists, biomedical engineers, nurses, and physiotherapists led by Dr. Angelo Toscano, medical director of the Rizzoli-Sicilia General Orthopedics Department, headed by Dr. Jacopo Frugiuele. Both patients had tumor masses located in particular, uncommon areas, which posed significant surgical difficulties.