Main container

New function of CD99 antigen identified

Rizzoli’s research into new therapeutic potential against Ewing’s Sarcoma

January 18th, 2024

The researchers, led by Dr. Katia Scotlandi, head of the Laboratory of Experimental Oncology at the IRCCS Orthopedic Institute Rizzoli, have identified an unprecedented function of the CD99 antigen. 

An antigen is a molecule that the immune system recognizes as foreign. In this case, the CD99 antigen is stimulated, through the recognition by specific antibodies, to induce the death of cancer cells. This can happen because CD99 determines the activation of so-called "eat me" signals and the inhibition of opposite signals, called "don’t eat me", on the surface of neoplastic cells. In turn, all this promotes the activity of phagocytosis by macrophages, cells of innate immunity able to engulf and neutralize cells and dangerous molecules. Since the CD99 antigen is also expressed on the same macrophages, the anti-CD99 antibodies also act on these cells, favoring the development of special M1 macrophages with anti-tumor characteristics. Overall, therefore, anti-CD99 antibodies attack the tumor on two fronts, acting both on cancer cells and on the tumor microenvironment, of which the macrophages are part. Among the most active antibodies is the human antibody C7, the use of which could have an important therapeutic potential against Ewing’s sarcoma and other cancer pathologies.

The study was conceived by researchers of the Laboratory of Experimental Oncology directed by Dr. Katia Scotlandi at the Rizzoli Orthopedic Institute. The research group of Dr. Gina Lisignoli of the Laboratory of Immunorheumatology and Tissue Regeneration has collaborated, which has made available its experience in the phenotypic characterization of macrophages, and the group of Dr. Francesca Salamanna, of Science and Surgical Technologies, as well as some researchers from the University of Bologna.

The results of the study, supported by the AIRC Foundation for Cancer Research, were recently published in the journal Cancer Immunology Research.

Le autrici principali dell’articolo: da sinistra Dr.ssa Salamanna, Dr.ssa Manara, Dr.ssa Scotlandi, Dr.ssa Lisignoli, Dr.ssa Cristalli e Dr.ssa Manfredini
The main authors of the article: from left Dr. Salamanna, Dr. Manara, Dr. Scotlandi, Dr. Lisignoli, Dr. Cristalli e Dr. Manferdini



You might also be interested in

Pronto Soccorso del Rizzoli
Four children from Gaza to Rizzoli in Bologna
Eleven people, children injured and companions welcomed in Paediatric Orthopaedics and Emergency room
Dr.ssa Gina Lisignoli e Dr.ssa Brunella Grigolo del Rizzoli
Women in research: two Rizzoli researchers contribute to an Opinion Paper on Frontiers
February 11th International Day of Women and Girls in Science
Il Dr. Giancarlo Facchini con Giulio
After years of pain operated at Rizzoli thanks to the angio-suite
Combined treatment of embolization and electrosclerotherapy for a 17-year-old boy